Selective Direct Borylation and Late-Stage Functionalization of 1,2-Azaborines

Bentley, Sierra Kathleen. “Selective Direct Borylation and Late-Stage Functionalization of 1,2-Azaborines”, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:109014.

Abstract

Described herein is the development of a method to directly borylate the C5-position of monocyclic 1,2-azaborines without the use of a metal catalyst, kinetic resolution or directing group. This method tolerates different substitution on the boron as well as at the C3-position of the azaborine. A new BN-isostere of the drug molecule, felbinac, was synthesized to demonstrate the application of this method.

Title
Selective Direct Borylation and Late-Stage Functionalization of 1,2-Azaborines
Author
Bentley, Sierra Kathleen
School
Arts and Sciences
Discipline
Chemistry
Publisher
Boston College
Date Issued
2020
Genre
thesis
Degree Level
Masters
Degree Name
MS
Thesis Advisor
Liu, Shih-Yuan
Persistent Link
http://hdl.handle.net/2345/bc-ir:109014
Use Restrictions
Copyright is held by the author. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0).
Subject
1,2-azaborines
Borylation
Scholarly Profile
Sierra Kathleen Bentley's ORCID:  https://orcid.org/0000-0001-6017-1432

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