Despite the Asian Indian community being one of the fastest growing populations in the U.S., there continues to be a paucity of research available that examines the specific nuances of the acculturation process within this population, particularly with regards Asian Indian women in the immigrant context within the U.S. Guided by a socioecological framework (Bronfenbrenner, 1994), the aim of this present study was to examine how Asian Indian immigrant women, who migrated to the U.S. between 1966-1985, have engaged in the acculturative process and made sense of their ethnic and gender identity across time. Utilizing a qualitative descriptive methodology, 18 participants (ages 55 to 71 years) were interviewed via a semistructured format. Conventional content analysis was used to analyze the data collected in this investigation and revealed six broad domains related to participants’ experiences as Asian Indian immigrant women living in the U.S. These domains include following: 1) marriage and family; 2) working in the U.S; 3) experiences of gender; 4) challenges to acculturation; 5) cxperience of immigration over time; and 6) coping and resilience. The findings from this study illuminate the ways in which gender is restructured within the immigrant context, the immigrant experience transforms over time, and the psychological impact of the acculturative process among the Asian Indian immigrant women population. Important implications for culturally informed clinical practice and future research directions are discussed.